THE LIFE LABORATORY 生命实验室

1.1 THE ROOT OF EVERYTHING

LIFE’S RECIPES

The key to all science is undoubtedly the question mark.

— Honoré de Balzac

The origin of life has long captivated scientists. Can the answer be found in a laboratory?

While scientific experiments have yet to provide definitive answers, they allow us to uncover structural details and formulate hypotheses – effectively creating and blending known ‘recipes.’ This is how this remarkable ‘cookbook’ is written. Shall we explore its most brilliant pages?

‘Primordial Soup’

Alexander Oparin, The Origin of Life (1924)

John Haldane, The Origin of Life (1929)

Hypothesis: Driven by solar radiation and electrical discharges, water molecules and mineral compounds in the ancient ocean synthesized into organic matter. This formed a ‘primordial soup’ in which life ultimately emerged.

‘Primordial Pizza’

John Maynard Smith and Eörs Szathmáry, The Major Transitions in Evolution (1995)

Hypothesis: Life originated as a thin layer of organic molecules organized on clay surfaces composed of microscopic aluminosilicate sheets. The minerals within the clay may have also served as catalysts for early biochemical reactions.

‘Primordial Mayonnaise’

Harold Morowitz, Mayonnaise and the Origin of Life: Thoughts of Minds and Molecules (1985)

Hypothesis: Clusters of self-replicating biomolecules – specifically ribonucleic acid (RNA) – were isolated from the environment within lipid vesicles, which functioned as primordial cell membranes.

1.1 万物之始

生命的“配方”

问号是开启一切科学之门的钥匙

—— 奥诺雷・德・巴尔扎克

生命起源问题长久困扰着科学家。我们能否在实验室找到答案?

科学实验目前尚不能给出确定结论,但可以厘清诸多细节、提出各类假说,组合甚至改写已有的生命“配方”。

一部奇妙的“科普食谱”就这样被书写而成。一起来品读其中最精彩的篇章吧!

“原始汤”

亚历山大·奥帕林《生命的起源》,1924年

约翰·霍尔丹《生命的起源》,1929年

假说: 远古大洋之中,在辐射、气体放电的作用下,水分子与矿物质合成有机物质,形成“原始汤”,生命便从中诞生。

“原始披萨”

约翰·梅纳德·史密斯和厄尔斯·萨撒玛里《生命的起源——从生命的诞生到语言的起源》,1995年

假说: 生命诞生于黏土表面一层薄薄的有机分子膜;黏土颗粒由铝硅酸盐薄层构成,黏土中的矿物同时起到催化剂的作用。

“原始蛋黄酱”

哈罗德·莫罗维茨《蛋黄酱与生命的起源: 心灵与分子的思考》,1985年

假说:具备自我复制能力的核糖核酸(RNA)生物分子聚集体,被脂质囊泡包裹,与外界环境隔离开来;脂质囊泡充当了细胞膜的角色。